Ontology highlight
ABSTRACT:
SUBMITTER: Kahn TG
PROVIDER: S-EPMC5137424 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nucleic acids research 20160823 21
Polycomb Group (PcG) proteins are epigenetic repressors essential for control of development and cell differentiation. They form multiple complexes of which PRC1 and PRC2 are evolutionary conserved and obligatory for repression. The targeting of PRC1 and PRC2 is poorly understood and was proposed to be hierarchical and involve tri-methylation of histone H3 (H3K27me3) and/or monoubiquitylation of histone H2A (H2AK118ub). Here, we present a strict test of this hypothesis using the Drosophila model ...[more]