Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Alonso L
PROVIDER: S-EPMC6522379 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Garcia-Alonso Luz L Iorio Francesco F Matchan Angela A Fonseca Nuno N Jaaks Patricia P Peat Gareth G Pignatelli Miguel M Falcone Fiammetta F Benes Cyril H CH Dunham Ian I Bignell Graham G McDade Simon S SS Garnett Mathew J MJ Saez-Rodriguez Julio J
Cancer research 20171211 3
Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer the transcriptional activity of 127 TFs through analysis of RNA-seq gene expression data newly generated for 448 cancer cell lines, combined with publicly available datasets to survey a total of 1,056 cancer cell lines and 9,250 primary tumors. Predicted TF activities are supported by their agreement with indep ...[more]