Ontology highlight
ABSTRACT:
SUBMITTER: Giagtzoglou N
PROVIDER: S-EPMC3744027 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Giagtzoglou Nikolaos N Li Tongchao T Yamamoto Shinya S Bellen Hugo J HJ
Journal of cell science 20130620 Pt 16
Notch signaling is an evolutionarily conserved pathway that plays a central role in numerous developmental and disease processes. The versatility of the Notch pathway relies on the activity of context-dependent regulators. These include rab11, sec15, arp3 and Drosophila EHBP1 (dEHBP1), which control Notch signaling and cell fate acquisition in asymmetrically dividing mechanosensory lineages by regulating the trafficking of the ligand Delta. Here, we show that dEHBP1 also controls the specificati ...[more]