Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization.
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ABSTRACT:
SUBMITTER: Pitingolo G
PROVIDER: S-EPMC6523541 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Gelatin-Coated Microfluidic Channels for 3D Microtissue Formation: On-Chip Production and Characterization.
Pitingolo Gabriele G Riaud Antoine A Nastruzzi Claudio C Taly Valerie V
Micromachines 20190419 4
Traditional two-dimensional (2D) cell culture models are limited in their ability to reproduce human structures and functions. On the contrary, three-dimensional (3D) microtissues have the potential to permit the development of new cell-based assays as advanced in vitro models to test new drugs. Here, we report the use of a dehydrated gelatin film to promote tumor cells aggregation and 3D microtissue formation. The simple and stable gelatin coating represents an alternative to conventional and e ...[more]
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