Ontology highlight
ABSTRACT:
SUBMITTER: Stringer C
PROVIDER: S-EPMC6525101 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Stringer Carsen C Pachitariu Marius M Steinmetz Nicholas N Reddy Charu Bai CB Carandini Matteo M Harris Kenneth D KD
Science (New York, N.Y.) 20190418 6437
Neuronal populations in sensory cortex produce variable responses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input. Cortical variability and spontaneous activity have been variously proposed to represent random noise, recall of prior experience, or encoding of ongoing behavioral and cognitive variables. Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, ...[more]