Dataset Information

Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.

ABSTRACT:

Background

This study investigated the associations of fluctuations in serum chloride (Cl^-) levels with 30-day mortality after intensive care unit (ICU) admission among critically ill patients.

Methods

We retrospectively analyzed the medical records of adult patients (?18?years old) admitted to the ICU between January 2012 and December 2017. Positive and negative fluctuations in Cl^- were defined as the differences between the Cl^- upon ICU admission (baseline Cl^-) and the maximum and minimum Cl^- levels, respectively, measured within 72?h after ICU admission.

Results

The final analysis included 18,825 adult patients. In multivariable Cox regression analyses, the risk of 30-day mortality increased by 8% per 1-mmol?L^-?1 positive fluctuation in Cl^- within 72?h (hazard ratio?=?1.08, 95% confidence interval: 1.04-1.11, P?- was associated with increased 30-day mortality among patients with a severe positive cumulative fluid balance (FB, >?10%), normochloremia (97-110?mmol?L^-?1) or hyperchloremia (>?110?mmol?L^-?1) upon ICU admission. Furthermore, a negative fluctuation in the Cl^- level during the first 72?h of an ICU stay was associated with a negative cumulative FB (-?1) upon ICU admission.

Conclusions

A fluctuation in the Cl^- level during the first 72?h of an ICU stay was found to associate independently with increased 30-day mortality among critically ill adult patients. However, the nature of this association differed according to the cumulative FB status or dyschloremia status upon ICU admission.

SUBMITTER: Kim HJ

PROVIDER: S-EPMC6525376 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.

Kim Hyo Jin HJ Oh Tak Kyu TK Song In-Ae IA Lee Jae Ho JH

BMC anesthesiology 20190517 1

<h4>Background</h4>This study investigated the associations of fluctuations in serum chloride (Cl<sup>-</sup>) levels with 30-day mortality after intensive care unit (ICU) admission among critically ill patients.<h4>Methods</h4>We retrospectively analyzed the medical records of adult patients (≥18 years old) admitted to the ICU between January 2012 and December 2017. Positive and negative fluctuations in Cl<sup>-</sup> were defined as the differences between the Cl<sup>-</sup> upon ICU admission ...[more]

PMID: 31101086

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Dataset Information

Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.

Background

Methods

Results

Conclusions

Publications

Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.

Similar Datasets

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