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Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.

ABSTRACT: CAPN5 Neovascular Inflammatory Vitreoretinopathy (CAPN5-NIV; OMIM 193235) is a poorly-understood rare, progressive inflammatory intraocular disease with limited therapeutic options. To profile disease effector proteins in CAPN5-NIV patient vitreous, liquid vitreous biopsies were collected from two groups: eyes from control subjects (n?=?4) with idiopathic macular holes (IMH) and eyes from test subjects (n?=?12) with different stages of CAPN5-NIV. Samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Protein expression changes were evaluated by principal component analysis, 1-way ANOVA (significant p-value?

SUBMITTER: Velez G

PROVIDER: S-EPMC6527583 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.

Velez Gabriel G Yang Jing J Li Angela S AS Tsang Stephen H SH Bassuk Alexander G AG Mahajan Vinit B VB

Scientific reports 20190520 1

CAPN5 Neovascular Inflammatory Vitreoretinopathy (CAPN5-NIV; OMIM 193235) is a poorly-understood rare, progressive inflammatory intraocular disease with limited therapeutic options. To profile disease effector proteins in CAPN5-NIV patient vitreous, liquid vitreous biopsies were collected from two groups: eyes from control subjects (n = 4) with idiopathic macular holes (IMH) and eyes from test subjects (n = 12) with different stages of CAPN5-NIV. Samples were analyzed by liquid chromatography-ta ...[more]

PMID: 31110225

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