Proteomics

Dataset Information

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Proteomic Insight into the Role of Exosomes in Proliferative Vitreoretinopathy Development


ABSTRACT: To characterize vitreous humor (VH) exosomes and to explore their role in the development of proliferative vitreoretinopathy (PVR) using mass-spectrometry based proteome profiling.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vitreous Chamber Of The Eye

DISEASE(S): Retinal Detachment,Proliferative Vitreoretinopathy,Macular Holes

SUBMITTER: Virginie Sjoelund  

LAB HEAD: Lee Sun Young

PROVIDER: PXD028539 | Pride | 2022-06-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
PVR003.mzML Mzml
PVR003.mzid.gz Mzid
PVR003.raw Raw
PVR004.raw Raw
PVR008.raw Raw
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Publications

Proteomic Insight into the Role of Exosomes in Proliferative Vitreoretinopathy Development.

Nair Gopa Kumar Gopinadhan GKG   Pollalis Dimitrios D   Wren Jonathan D JD   Georgescu Constantin C   Sjoelund Virginie V   Lee Sun Young SY  

Journal of clinical medicine 20220511 10


<b>Purpose</b>: To characterize vitreous humor (VH) exosomes and to explore their role in the development of proliferative vitreoretinopathy (PVR) using mass spectrometry-based proteome profiling. <b>Methods</b>: Exosomes were isolated from undiluted VH from patients with retinal detachment (RD) with various stages of PVR (<i>n</i> = 9), macular hole (MH; <i>n</i> = 5), or epiretinal membrane (ERM; <i>n</i> = 5) using differential ultracentrifugation. The exosomal size, morphology, and exosome m  ...[more]

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