Dataset Information

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis protocol.

ABSTRACT:

Background

Hepatitis E virus (HEV) is one of the major causes of acute hepatitis in humans worldwide with a case-fatality rate of 1-4% in the general population that might reach 30% in pregnant women. In the past decade in Africa, studies have shown that HEV infects not only humans but also animals. A systematic review summarizing the epidemiological data of HEV has been only performed in humans residing in Africa. We will perform this systematic review and meta-analysis to assess the prevalence of HEV infection in animal species in Africa.

Methods

This review will include cross-sectional studies among different animal species that reported the prevalence of HEV in Africa. We will consider published and unpublished studies from January 1, 2000 to present. A comprehensive search of PubMed, Excerpta Medica, African Journals Online, and Africa Index Medicus will be conducted to identify all relevant articles. Reference lists of eligible items and relevant articles will be reviewed. The funnel plots and the Egger test will be used to assess the publication bias. Study-specific estimates will be aggregated using a DerSimonian and Laird random-effects meta-analysis model to obtain an overall summary estimate of HEV prevalence across studies. The heterogeneity of the studies will be evaluated by the ?2 test on the Cochran's Q test. The results will be presented by animal species.

Discussion

HEV-infected animals are likely to transmit this virus to humans in Africa, as studies have already shown in developed countries. This systematic review and meta-analysis will provide a clear picture of the epidemiology of HEV in animals in Africa, to better understand this infection and to respond adequately to the epidemic challenges that often afflict Africa.

Systematic review registration

PROSPERO, CRD42018087684 .

SUBMITTER: Modiyinji AF

PROVIDER: S-EPMC6528234 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis protocol.

Modiyinji Abdou Fatawou AF Bigna Jean Joel JJ Simo Fredy Brice N FBN Nola Moise M Ndangang Marie S MS Kenmoe Sebastien S Njouom Richard R

Systematic reviews 20190520 1

<h4>Background</h4>Hepatitis E virus (HEV) is one of the major causes of acute hepatitis in humans worldwide with a case-fatality rate of 1-4% in the general population that might reach 30% in pregnant women. In the past decade in Africa, studies have shown that HEV infects not only humans but also animals. A systematic review summarizing the epidemiological data of HEV has been only performed in humans residing in Africa. We will perform this systematic review and meta-analysis to assess the pr ...[more]

PMID: 31109366

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Dataset Information

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis protocol.

Background

Methods

Discussion

Systematic review registration

Publications

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis protocol.

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