Ontology highlight
ABSTRACT:
SUBMITTER: Sun M
PROVIDER: S-EPMC6528466 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Sun Miao M Huang Chengyu C Wang Hui H Zhang Huaye H
Neurobiology of aging 20190130
The convergence between amyloid precursor protein (APP) and its β-secretase β-site APP cleaving enzyme 1 (BACE1) is a prerequisite for the generation of β-amyloid peptide, a key pathogenic agent for Alzheimer's disease. Yet the underlying molecular mechanisms regulating their convergence remain unclear. Here, we show that the polarity protein partitioning-defective 3 (Par3) regulates the polarized convergence between APP and BACE1 in hippocampal neurons. Par3 forms a complex with BACE1 through i ...[more]