Ontology highlight
ABSTRACT:
SUBMITTER: Nicolas L
PROVIDER: S-EPMC6529280 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nicolas Laura L Cols Montserrat M Smolkin Ryan R Fernandez Keith C KC Yewdell William T WT Yen Wei-Feng WF Zha Shan S Vuong Bao Q BQ Chaudhuri Jayanta J
Journal of immunology (Baltimore, Md. : 1950) 20190426 11
The DNA damage response protein ATM has long been known to influence class switch recombination in ex vivo-cultured B cells. However, an assessment of B cell-intrinsic requirement of ATM in humoral responses in vivo was confounded by the fact that its germline deletion affects T cell function, and B:T cell interactions are critical for in vivo immune responses. In this study, we demonstrate that B cell-specific deletion of ATM in mice leads to reduction in germinal center (GC) frequency and size ...[more]