Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman JR
PROVIDER: S-EPMC6529881 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Learning & memory (Cold Spring Harbor, N.Y.) 20190520 6
Beta-adrenergic receptors (β-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of β-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during β-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to downstream signaling proteins. We hypothesized that induction of this metaplasticity requires intact functioning of AKAPs. Acute application of stearated ht31, a membrane-permean ...[more]