Ontology highlight
ABSTRACT:
SUBMITTER: Bazzill JD
PROVIDER: S-EPMC6531357 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Bazzill Joseph D JD Stronsky Sabrina M SM Kalinyak Laura C LC Ochyl Lukasz J LJ Steffens Jesse T JT van Tongeren Sean A SA Cooper Christopher L CL Moon James J JJ
Nanomedicine : nanotechnology, biology, and medicine 20181122
The recent outbreaks of Ebolavirus (EBOV) in West Africa underscore the urgent need to develop an effective EBOV vaccine. Here, we report the development of synthetic nanoparticles as a safe and highly immunogenic platform for vaccination against EBOV. We show that a large recombinant EBOV antigen (rGP) can be incorporated in a configurational manner into lipid-based nanoparticles, termed interbilayer-crosslinked multilamellar vesicles (ICMVs). The epitopes and quaternary structure of rGP were p ...[more]