Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC6950126 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Xu Shengnan S Jiao Cuicui C Jin Hongli H Li Wujian W Li Entao E Cao Zengguo Z Shi Zhikang Z Yan Feihu F Zhang Shengnan S He Hongbin H Chi Hang H Feng Na N Zhao Yongkun Y Gao Yuwei Y Yang Songtao S Wang Jianzhong J Wang Hualei H Xia Xianzhu X
Viruses 20191211 12
Sudan virus (SUDV) causes severe lethal hemorrhagic fever in humans and nonhuman primates. The most effective and economical way to protect against Sudan ebolavirus disease is prophylactic vaccination. However, there are no licensed vaccines to prevent SUDV infections. In this study, a bacterium-like particle (BLP)-based vaccine displaying the extracellular domain of the SUDV glycoprotein (eGP) was developed based on a gram-positive enhancer matrix-protein anchor (GEM-PA) surface display system. ...[more]