Ontology highlight
ABSTRACT:
SUBMITTER: Abbasov ME
PROVIDER: S-EPMC6532426 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Abbasov Mikail E ME Alvariño Rebeca R Chaheine Christian M CM Alonso Eva E Sánchez Jon A JA Conner Michael L ML Alfonso Amparo A Jaspars Marcel M Botana Luis M LM Romo Daniel D
Nature chemistry 20190322 4
The architecture and bioactivity of natural products frequently serve as embarkation points for the exploration of biologically relevant chemical space. Total synthesis followed by derivative synthesis has historically enabled a deeper understanding of structure-activity relationships. However, synthetic strategies towards a natural product are not always guided by hypotheses regarding the structural features required for bioactivity. Here, we report an approach to natural product total synthesi ...[more]