Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood.
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ABSTRACT:
SUBMITTER: Morriss J
PROVIDER: S-EPMC6533253 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood.
Morriss Jayne J Christakou Anastasia A van Reekum Carien M CM
Scientific reports 20190523 1
Previous research in rodents and humans points to an evolutionarily conserved profile of blunted threat extinction learning during adolescence, underpinned by brain structures such as the amygdala and medial prefrontal cortex (mPFC). In this study, we examine age-related effects on the function and structural connectivity of this system in threat extinction learning in adolescence and young adulthood. Younger age was associated with greater amygdala activity and later engagement of the mPFC to l ...[more]
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