Ontology highlight
ABSTRACT:
SUBMITTER: Lill D
PROVIDER: S-EPMC6533310 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lill Daniel D Rukhlenko Oleksii S OS Mc Elwee Anthony James AJ Kashdan Eugene E Timmer Jens J Kholodenko Boris N BN
NPJ systems biology and applications 20190523
Modular Response Analysis (MRA) is a suite of methods that under certain assumptions permits the precise reconstruction of both the directions and strengths of connections between network modules from network responses to perturbations. Standard MRA assumes that modules are insulated, thereby neglecting the existence of inter-modular protein complexes. Such complexes sequester proteins from different modules and propagate perturbations to the protein abundance of a downstream module retroactivel ...[more]