Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC6533482 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Liu Man M Xiao Cheng-Qian CQ Sun Ming-Wei MW Tan Min-Jia MJ Hu Li-Hong LH Yu Qiang Q
Journal of cellular and molecular medicine 20190416 6
Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor-κB (NF-κB) signalling pathways is associated with the development of cancer and inflammatory diseases. JAKs and IKKs are the key regulators in the STAT3 and NF-κB signalling respectively. Therefore, the two families of kinases have been the major targets for developing drugs to regulate the two signalling pathways. Here, we report a natural compound xanthatin from the traditional Chinese ...[more]