Ontology highlight
ABSTRACT:
SUBMITTER: Li JH
PROVIDER: S-EPMC6533527 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Li Jin H JH Tang Ying Y Lv Jun J Wang Xiao H XH Yang Hui H Tang Patrick M K PMK Huang Xiao R XR He Zhi J ZJ Zhou Zi J ZJ Huang Qiu Y QY Klug Jörg J Meinhardt Andreas A Fingerle-Rowson Günter G Xu An P AP Zheng Zhi H ZH Lan Hui Yao HY
Journal of cellular and molecular medicine 20190409 6
Macrophage migration inhibitory factor (MIF) is pleiotropic cytokine that has multiple effects in many inflammatory and immune diseases. This study reveals a potential role of MIF in acute kidney injury (AKI) in patients and in kidney ischemic reperfusion injury (IRI) mouse model in MIF wild-type (WT) and MIF knockout (KO) mice. Clinically, plasma and urinary MIF levels were largely elevated at the onset of AKI, declined to normal levels when AKI was resolved and correlated tightly with serum cr ...[more]