Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC7028360 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sun Xiaoli X Seidman Jason S JS Zhao Peng P Troutman Ty D TD Spann Nathanael J NJ Que Xuchu X Zhou Fangli F Liao Zhongji Z Pasillas Martina M Yang Xiaohong X Magida Jason A JA Kisseleva Tatiana T Brenner David A DA Downes Michael M Evans Ronald M RM Saltiel Alan R AR Tsimikas Sotirios S Glass Christopher K CK Witztum Joseph L JL
Cell metabolism 20191121 1
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. Here, we show that OxPLs accumulate in human and mouse NASH. Using a transgenic mouse that expresses a functional single-chain variable fragment of E06, a natural antibody that neutralizes OxPLs, we demonstrate the causal role of OxPLs in NASH. Targeting OxPLs in hyperlipidemic Ldlr<sup>-/-</sup> mice improved multiple a ...[more]