Ontology highlight
ABSTRACT:
SUBMITTER: Hirata Y
PROVIDER: S-EPMC6534147 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hirata Yuichi Y Furuhashi Kazuhiro K Ishii Hiroshi H Li Hao Wei HW Pinho Sandra S Ding Lei L Robson Simon C SC Frenette Paul S PS Fujisaki Joji J
Cell stem cell 20180215 3
A crucial player in immune regulation, FoxP3<sup>+</sup> regulatory T cells (Tregs) are drawing attention for their heterogeneity and noncanonical functions. Here, we describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment. These Tregs highly expressed an HSC marker, CD150, and localized within the HSC niche in the bone marrow (BM). Specific reduction of BM Tregs achieved by conditional deletion of CXCR4 in Tregs increased HSC numbers in the BM. Adeno ...[more]