Ontology highlight
ABSTRACT:
SUBMITTER: Ying Y
PROVIDER: S-EPMC6535073 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ying Yin Y Jiang Cheng C Zhang Meiling M Jin Jiye J Ge Shuyu S Wang Xiaodong X
Aging 20190501 9
Diabetic cardiomyopathy increases the risk of heart failure independent of coronary artery disease and hypertension. Phloretin (PHL) shows anti-inflammatory effects in macrophages. In this study, we explored the protective effects of PHL on high glucose (HG)-induced injury in diabetic cardiomyopathy <i>in vivo</i> and <i>in vitro</i>. Using streptozotocin-induced diabetic mouse model and incubating cardiac cells line under a HG environment, PHL were evaluated of the activities of anti-inflammati ...[more]