Ontology highlight
ABSTRACT:
SUBMITTER: Saini V
PROVIDER: S-EPMC6535519 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Saini Vikram V Ammerman Nicole C NC Chang Yong Seok YS Tasneen Rokeya R Chaisson Richard E RE Jain Sanjay S Nuermberger Eric E Grosset Jacques H JH
Antimicrobial agents and chemotherapy 20190524 6
Clofazimine and high-dose rifapentine have each separately been associated with treatment-shortening activity when incorporated into tuberculosis (TB) treatment regimens. We hypothesized that both modifications, i.e., the addition of clofazimine and the replacement of rifampin with high-dose rifapentine, in the first-line regimen for drug-susceptible TB would significantly shorten the duration of treatment necessary for cure. We tested this hypothesis in a well-established BALB/c mouse model of ...[more]