Dataset Information
In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus.
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ABSTRACT:
SUBMITTER: Kaushik A
PROVIDER: S-EPMC6535573 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
<i>In Vitro</i> Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of <i>Mycobacterium abscessus</i>.
Antimicrobial agents and chemotherapy 20190524 6
Tigecycline is used in multidrug regimens for salvage therapy of <i>Mycobacterium abscessus</i> infections but is often poorly tolerated and has no oral formulation. Here, we report similar <i>in vitro</i> activity of two newly approved tetracycline analogs, omadacycline and eravacycline, against 28 drug-resistant clinical isolates of <i>M. abscessus</i> complex. Since omadacycline and eravacycline appear to be better tolerated than tigecycline and since omadacycline is also formulated for oral ...[more]
