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Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.

ABSTRACT: A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.

SUBMITTER: Dedrick RM

PROVIDER: S-EPMC6557439 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.

Dedrick Rebekah M RM Guerrero-Bustamante Carlos A CA Garlena Rebecca A RA Russell Daniel A DA Ford Katrina K Harris Kathryn K Gilmour Kimberly C KC Soothill James J Jacobs-Sera Deborah D Schooley Robert T RT Hatfull Graham F GF Spencer Helen H

Nature medicine 20190508 5

A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantia ...[more]

PMID: 31068712

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Mycobacteriophage-antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus.

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Mycobacterium abscessus drug discovery using machine learning.

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