Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6535787 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Li Li L Yu Shijun S Wu Qiong Q Dou Ning N Li Yandong Y Gao Yong Y
International journal of biological sciences 20190310 5
P-cadherin (CDH3), a classical cell adhesion molecule involved in tissue integrity and cell localization, has been implicated in many types of cancer. However, little is known about its function and regulatory mechanism in hepatocellular carcinoma (HCC). Here we report that CDH3 was positively regulated by kr¨uppel-like transcription factor 4 (KLF4), which is a crucial tumor suppressor gene in HCC, at mRNA level in HCC cell lines. Luciferase reporter assay and chromatin immunoprecipitation assay ...[more]