Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.
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ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC6535981 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.
Chen Timothy T Vunjak-Novakovic Gordana G
Tissue engineering. Part A 20181120 9-10
<h4>Impact statement</h4>Reducing ischemia-reperfusion injury would significantly improve patient survival. Current preclinical models are inadequate because they rely on animals, which do not emulate human physiology and the clinical setting. We developed a human tissue platform that allowed us to assess the human cardiac response, and demonstrated the platform's utility by measuring injury during ischemia-reperfusion and the effects of cardioprotective strategies. The model provides a foundati ...[more]
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