Ontology highlight
ABSTRACT:
SUBMITTER: Vanyai HK
PROVIDER: S-EPMC7673359 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Vanyai Hannah K HK Prin Fabrice F Guillermin Oriane O Marzook Bishara B Boeing Stefan S Howson Alexander A Saunders Rebecca E RE Snoeks Thomas T Howell Michael M Mohun Timothy J TJ Thompson Barry B
Development (Cambridge, England) 20201112 21
The Hippo-YAP/TAZ pathway is an important regulator of tissue growth, but can also control cell fate or tissue morphogenesis. Here, we investigate the function of the Hippo pathway during the development of cartilage, which forms the majority of the skeleton. Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation. We find that, <i>in vitro</i>, <i>Yap</i>/<i>Taz</i> double knockout impairs murine chondrocyte proliferation, whereas consti ...[more]