Ontology highlight
ABSTRACT:
SUBMITTER: Zahorchak AF
PROVIDER: S-EPMC6537105 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zahorchak Alan F AF Perez-Gutierrez Angelica A Ezzelarab Mohamed B MB Thomson Angus W AW
Cellular immunology 20180427
Putative monocytic myeloid-derived suppressor cells (mMDSC; lineage<sup>-</sup>HLA-DR<sup>-/lo</sup>) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on their differential expression of CD14, CD33, CD34 and CD11b. Following flow sorting, assessment of the capacity of these subsets to suppress anti-CD3/CD28-stimulated CD4 and CD8 T cell proliferation revealed that the most potent population was CD14<sup>hi< ...[more]