Ontology highlight
ABSTRACT:
SUBMITTER: Wu KJ
PROVIDER: S-EPMC6538288 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cell reports 20190501 8
Mycobacterium tuberculosis, the causative agent of tuberculosis, withstands diverse environmental stresses in the host. The periplasmic protease HtrA is required only to survive extreme conditions in most bacteria but is predicted to be essential for normal growth in mycobacteria. We confirm that HtrA is indeed essential in Mycobacterium smegmatis and interacts with another essential protein of unknown function, LppZ. However, the loss of any of three unlinked genes, including those encoding Ami ...[more]