Dataset Information

Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity.

ABSTRACT: BACKGROUND:Studies associate sleeping and eating late in the day with poor dietary quality and higher obesity risk but differences in sleep duration confound this association. We aimed to determine whether sleep and meal timing, independent of sleep duration, influenced food intake in healthy adults. METHODS:This was a controlled, 2?×?2 inpatient crossover study with normal (0000-0800?h) or late (0330-1130?h) sleep and normal (1, 5, 11, and 12.5?h after awakening) or late (4.5, 8.5, 14.5, and 16?h after awakening) meals. Food intake was controlled while blood samples were obtained for determination of appetite-regulating hormones on days 3-4. Self-selected food intake was assessed on day 5. Data were analyzed using linear mixed model analysis with sleep, meal, and sleep x meal interaction as dependent variables. RESULTS:Five participants completed all phases (mean age 25.1?±?[SD] 3.9?y, body mass index 29.2?±?2.7?kg/m2). There was a significant sleep x meal interaction on energy intake (P?=?0.035) and trends on fat and sodium intakes (P?

SUBMITTER: St-Onge MP

PROVIDER: S-EPMC6538463 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity.

St-Onge Marie-Pierre MP Pizinger Theresa T Kovtun Kyle K RoyChoudhury Arindam A

European journal of clinical nutrition 20190701 Suppl 1

<h4>Background</h4>Studies associate sleeping and eating late in the day with poor dietary quality and higher obesity risk but differences in sleep duration confound this association. We aimed to determine whether sleep and meal timing, independent of sleep duration, influenced food intake in healthy adults.<h4>Methods</h4>This was a controlled, 2 × 2 inpatient crossover study with normal (0000-0800 h) or late (0330-1130 h) sleep and normal (1, 5, 11, and 12.5 h after awakening) or late (4.5, 8. ...[more]

PMID: 30487565

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Project description:BACKGROUND/OBJECTIVES:Experiments in animal models have shown a positive association between in utero exposure to pharmacologic sex hormones and offspring obesity. The developmental effects of such hormones on human obesity are unknown. SUBJECTS/METHODS:Using data from a large, prospective pregnancy cohort study (n=19?652), with linkage to a national prescription registry, we evaluated the association between use of hormonal contraceptives before and after conception (defined from dispensed prescription data and characterized by last date of use relative to conception, 12 to >4 months before (n=3392), 4 to >1 months before (n=2541), 1 to >0 months before (n=2997) and 0-12 weeks after (n=567)) in relation to offspring overweight or obesity at age 3 years. RESULTS:We observed a weak, inverse association between early pregnancy use of a combination oral contraceptive and offspring overweight or obesity at age 3 (adjusted odds ratio (OR): 0.75, 95% confidence interval (CI): 0.53, 1.08) and a positive, but imprecise, association with use of a progestin-only oral contraceptive in early pregnancy (adjusted OR: 1.26, 95% CI: 0.79, 2.02). In general, no association was observed between the use of a hormonal contraceptive before conception and offspring overweight or obesity. A sensitivity analysis comparing combination oral contraceptive users in early pregnancy to other unplanned pregnancies without hormonal contraceptive use further strengthened the inverse association (adjusted OR: 0.70, 95% CI: 0.48, 1.02). Other sensitivity analyses were conducted to evaluate the robustness of the associations observed given varying assumptions. CONCLUSIONS:Pharmacologic sex hormones in early pregnancy may be inversely or positively associated with offspring overweight or obesity at age 3, depending on the specific formulation used. The present study provides support for the potential for environmental sources of hormonally active agents to exert developmental effects.

Dataset Information

Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity.

Publications

Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity.

Similar Datasets

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