Ontology highlight
ABSTRACT:
SUBMITTER: Chalermrujinanant C
PROVIDER: S-EPMC6538526 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Chalermrujinanant C C Michowski W W Sittithumcharee G G Esashi F F Jirawatnotai S S
Oncogene 20150921 22
BRCA2 has an important role in the maintenance of genome stability by interacting with RAD51 recombinase through its C-terminal domain. This interaction is abrogated by cyclin A-CDK2-mediated phosphorylation of BRCA2 at serine 3291 (Ser3291). Recently, we showed that cyclin D1 facilitates RAD51 recruitment to BRCA2-containing DNA repair foci, and that downregulation of cyclin D1 leads to inefficient homologous-mediated DNA repair. Here, we demonstrate that cyclin D1, via amino acids 20-90, inter ...[more]