Ontology highlight
ABSTRACT:
SUBMITTER: Sidhu A
PROVIDER: S-EPMC7515699 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Sidhu Arshdeep A Grosbart Małgorzata M Sánchez Humberto H Verhagen Bram B van der Zon Nick L L NLL Ristić Dejan D van Rossum-Fikkert Sarah E SE Wyman Claire C
Nucleic acids research 20200901 17
BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sample a broad range of conformational space. We expect that the resulting dynamic arrangements of BRCA2 domains are a functionally important aspect of its role in homologous recombination DNA repair. To determine the architectural organization and the associated conformational landscape of BRCA2, we used scanning ...[more]