Delineating the role of eIF2? in retinal degeneration.
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ABSTRACT:
SUBMITTER: Starr CR
PROVIDER: S-EPMC6538684 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Delineating the role of eIF2α in retinal degeneration.
Starr Christopher R CR Gorbatyuk Marina S MS
Cell death & disease 20190528 6
Activation of the unfolded protein response has been detected in various animal models of retinal degeneration. The PERK branch converges on eIF2α to regulate protein synthesis. We previously reported that diseased retinas produce less protein as they degenerate. We also proposed that the majority of this reduction in protein synthesis may not be due to control of eIF2α. Nevertheless, multiple research groups have reported that modulating eIF2α levels may be a viable strategy in the treatment of ...[more]
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