Dataset Information

Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NF?B Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells.

ABSTRACT: Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NF?B). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NF?B signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NF?B activation that can lead to numerous diseases.

SUBMITTER: Giriwono PE

PROVIDER: S-EPMC6540148 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells.

Giriwono Puspo E PE Shirakawa Hitoshi H Ohsaki Yusuke Y Sato Shoko S Aoyama Yukihide Y Ho Hsin-Jung HJ Goto Tomoko T Komai Michio M

International journal of molecular sciences 20190510 9

Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppr ...[more]

PMID: 31083375

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Dataset Information

Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NF?B Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells.

Publications

Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells.

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