Ontology highlight
ABSTRACT:
SUBMITTER: Zhou D
PROVIDER: S-EPMC6540755 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhou Dalee D Ota Koji K Nardin Charlee C Feldman Michelle M Widman Adam A Wind Olivia O Simon Amanda A Reilly Michael M Levin Lonny R LR Buck Jochen J Wakamatsu Kazumasa K Ito Shosuke S Zippin Jonathan H JH
Science signaling 20181106 555
The production of melanin increases skin pigmentation and reduces the risk of skin cancer. Melanin production depends on the pH of melanosomes, which are more acidic in lighter-skinned than in darker-skinned people. We showed that inhibition of soluble adenylyl cyclase (sAC) controlled pigmentation by increasing the pH of melanosomes both in cells and in vivo. Distinct from the canonical melanocortin 1 receptor (MC1R)-dependent cAMP pathway that controls pigmentation by altering gene expression, ...[more]