Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC6540875 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wu Jun J Cheng Ziyun Z Xu Xiaofeng X Fu Jian J Wang Kaiyue K Liu Tao T Wu Chan C Kong Xiangyi X Yang Qian Q Yan Guijun G Zhou Huaijun H
Frontiers in oncology 20190522
Endometrial cancer (EC) is the most common gynecological tumor all over the world, and advanced/metastatic EC remains a malignancy with poor survival outcome due to highly resistant to conventional chemotherapeutic treatment. Here, we report that Aurora-A, a serine-threonine kinase, plays a vital role in chemoresistance of EC. Aurora-A is overexpressed in EC tissues, compared with normal endometrium and Aurora-A expression is associated with decreased overall survival. Overexpression of Aurora-A ...[more]