Ontology highlight
ABSTRACT:
SUBMITTER: Geldenhuys WJ
PROVIDER: S-EPMC6542280 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20190201 7
Nutrient-deprivation autophagy factor-1 (NAF-1, miner1; gene cisd2) is part of the [2Fe-2S]-containing protein family which includes mitoNEET (gene cisd1) and MiNT (miner2; gene cisd3). These proteins are redox active and are thought to play an important role in cellular energy homeostasis with NAF-1 playing a critical role in calcium regulation and aging. To date, no studies have investigated potential ligand interaction with NAF-1. Here we show that the thiazolidinediones pioglitazone and rosi ...[more]