Ontology highlight
ABSTRACT:
SUBMITTER: Cha-Molstad H
PROVIDER: S-EPMC4490096 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cha-Molstad Hyunjoo H Sung Ki Sa KS Hwang Joonsung J Kim Kyoung A KA Yu Ji Eun JE Yoo Young Dong YD Jang Jun Min JM Han Dong Hoon DH Molstad Michael M Kim Jung Gi JG Lee Yoon Jee YJ Zakrzewska Adriana A Kim Su-Hyeon SH Kim Sung Tae ST Kim Sun Yong SY Lee Hee Gu HG Soung Nak Kyun NK Ahn Jong Seog JS Ciechanover Aaron A Kim Bo Yeon BY Kwon Yong Tae YT
Nature cell biology 20150615 7
We show that ATE1-encoded Arg-transfer RNA transferase (R-transferase) of the N-end rule pathway mediates N-terminal arginylation of multiple endoplasmic reticulum (ER)-residing chaperones, leading to their cytosolic relocalization and turnover. N-terminal arginylation of BiP (also known as GRP78), protein disulphide isomerase and calreticulin is co-induced with autophagy during innate immune responses to cytosolic foreign DNA or proteasomal inhibition, associated with increased ubiquitylation. ...[more]