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The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia.

ABSTRACT: AIM:To investigate the relationship between the polymorphism of related gene loci of miRNAs regulated fibrinopeptide A and schizophrenia. Lay the foundation for the aetiology of schizophrenia. METHODS:Adapt to the phase match of sex and age case-control study, a total of 513 Chinese Han patients with schizophrenia were selected as the case group, 513 normal healthy persons as a control group. Obtaining SNPs information of the FGA gene by querying the dbSNP database, and reference HapMap database included SNPs site frequency information for screening. The frequency distributions of SNPs were genotyped by iMLDR® SNP detection technology. Two SNPs (pre-hsa-miR-605rs2043556 T>C, pre-hsa-miR-499a/pre-hsa-miR-499brs4909237 T < C) were analyzed to demonstrate their association with susceptibility to schizophrenia. RESULTS:There were no significant differences between patients and controls in genotype and allele distribution of SNPs rs2043556 and rs4909237 in the precursor region of hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b. Their gene-gene interaction, which suggests that the polymorphisms of miRNA genes might not contribute to schizophrenia susceptibility in the Han Chinese population. CONCLUSION:No significant difference existed between schizophrenic patients and controls in SNP (rs2043556 and rs4909237) in the precursor region of hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b. There may not regulate FGA gene expression. Thus, hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b may not influence the risks of schizophrenia.

SUBMITTER: Cao B

PROVIDER: S-EPMC6542391 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia.

Cao Bonan B Yang Mingjia M Kang Guojun G Li Rixin R Zhu Xiaojing X Kang Qi Q Sun Yaoyao Y Zhang Mingyuan M Wang Yueying Y Chen Xin X Yu Qiong Q

Open access Macedonian journal of medical sciences 20190515 9

<h4>Aim</h4>To investigate the relationship between the polymorphism of related gene loci of miRNAs regulated fibrinopeptide A and schizophrenia. Lay the foundation for the aetiology of schizophrenia.<h4>Methods</h4>Adapt to the phase match of sex and age case-control study, a total of 513 Chinese Han patients with schizophrenia were selected as the case group, 513 normal healthy persons as a control group. Obtaining SNPs information of the FGA gene by querying the dbSNP database, and reference ...[more]

PMID: 31198450

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Project description:BackgroundVarious lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis of schizophrenia. IL-6 mediated inflammatory response triggered by maternal infection or stress induces disruption of prenatal hippocampal development which might contribute towards psychopathology during adulthood. There is a substantial lack of knowledge on how genetic predisposition to elevated IL-6 expression effects hippocampal structure in schizophrenia patients. In this first-time study, we evaluated the relationship between functional polymorphism rs1800795 of IL-6 and hippocampal gray matter volume in antipsychotic-naïve schizophrenia patients in comparison with healthy controls.MethodologyWe examined antipsychotic-naïve schizophrenia patients [N = 28] in comparison with healthy controls [N = 37] group matched on age, sex and handedness. Using 3 Tesla - MRI, bilateral hippocampi were manually segmented by blinded raters with good inter-rater reliability using a valid method. Additionally, Voxel-based Morphometry (VBM) analysis was performed using hippocampal mask. The IL-6 level was measured in blood plasma using ELISA technique. SNP rs1800795 was genotyped using PCR and DNA sequencing. Psychotic symptoms were assessed using Scale for Assessment of Positive Symptoms and Scale for Assessment of Negative Symptoms.ResultsSchizophrenia patients had significantly deficient left and right hippocampal volumes after controlling for the potential confounding effects of age, sex and total brain volume. Plasma IL-6 levels were significantly higher in patients than controls. There was a significant diagnosis by rs1800795 genotype interaction involving both right and left hippocampal volumes. Interestingly, this effect was significant only in men but not in women.ConclusionOur first time observations suggest a significant relationship between IL-6 rs1800795 and reduced hippocampal volume in antipsychotic-naïve schizophrenia. Moreover, this relationship was antithetical in healthy controls and this effect was observed in men but not in women. Together, these observations support a "differential susceptibility" effect of rs1800795 in schizophrenia pathogenesis mediated through hippocampal volume deficit that is of possible neurodevelopmental origin.

Dataset Information

The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia.

Publications

The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia.

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