Ontology highlight
ABSTRACT:
SUBMITTER: Donadei C
PROVIDER: S-EPMC6542617 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Donadei Chiara C Angeletti Andrea A Cantarelli Chiara C D'Agati Vivette D VD La Manna Gaetano G Fiaccadori Enrico E Horwitz Julian K JK Xiong Huabao H Guglielmo Chiara C Hartzell Susan S Madsen Joren C JC Maggiore Umberto U Heeger Peter S PS Cravedi Paolo P
JCI insight 20190423
IL-17-producing CD4+ cells (TH17) are pathogenically linked to autoimmunity including to autoimmune kidney disease. Erythropoietin's (EPO) newly recognized immunoregulatory functions and its predominant intra-renal source suggested that EPO physiologically regulates TH17 differentiation, thereby serving as a barrier to the development of autoimmune kidney disease. Using in vitro studies of human and murine cells and in vivo models, we show that EPO ligation of its receptor (EPO-R) on CD4+ T cell ...[more]