Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Aranda M
PROVIDER: S-EPMC6321604 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
García-Aranda Marilina M Pérez-Ruiz Elisabet E Redondo Maximino M
International journal of molecular sciences 20181208 12
<b>A</b><b>bstract:</b> According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to ...[more]