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Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.


ABSTRACT: Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.

SUBMITTER: Garcia-Aranda M 

PROVIDER: S-EPMC6321604 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.

García-Aranda Marilina M   Pérez-Ruiz Elisabet E   Redondo Maximino M  

International journal of molecular sciences 20181208 12


<b>A</b><b>bstract:</b> According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to  ...[more]

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