Ontology highlight
ABSTRACT:
SUBMITTER: Bennett SA
PROVIDER: S-EPMC6543847 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Bennett Seth A SA Cobos Samantha N SN Meykler Marcella M Fallah Michel M Rana Navin N Chen Karen K Torrente Mariana P MP
Journal of visualized experiments : JoVE 20190324 145
Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), cause the loss of hundreds of thousands of lives each year. Effective treatment options able to halt disease progression are lacking. Despite the extensive sequencing efforts in large patient populations, the majority of ALS and PD cases remain unexplained by genetic mutations alone. Epigenetics mechanisms, such as the post-translational modification of histone proteins, may be involved in neuro ...[more]