Unknown

Dataset Information

0

Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.


ABSTRACT: BACKGROUND:Hypoglycemia is an increasingly recognized complication of bariatric surgery. Mechanisms contributing to glucose lowering remain incompletely understood. We aimed to identify differentially abundant plasma proteins in patients with post-bariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB), compared to asymptomatic post-RYGB. METHODS:Proteomic analysis of blood samples collected after overnight fast and mixed meal challenge in individuals with PBH, asymptomatic RYGB, severe obesity, or overweight recruited from outpatient hypoglycemia or bariatric clinics. RESULTS:The top-ranking differentially abundant protein at 120 min after mixed meal was fibroblast growth factor 19 (FGF-19), an intestinally derived hormone regulated by bile acid-FXR signaling; levels were 2.4-fold higher in PBH vs. asymptomatic post-RYGB (mean + SEM, 1094?±?141 vs. 428?±?45, P?

SUBMITTER: Mulla CM 

PROVIDER: S-EPMC6544487 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Background</h4>Hypoglycemia is an increasingly recognized complication of bariatric surgery. Mechanisms contributing to glucose lowering remain incompletely understood. We aimed to identify differentially abundant plasma proteins in patients with post-bariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB), compared to asymptomatic post-RYGB.<h4>Methods</h4>Proteomic analysis of blood samples collected after overnight fast and mixed meal challenge in individuals with PBH, asymptom  ...[more]

Similar Datasets

| S-EPMC8426371 | biostudies-literature
| S-EPMC8277212 | biostudies-literature
| S-EPMC3789357 | biostudies-literature
| S-EPMC7766790 | biostudies-literature
| S-EPMC7846180 | biostudies-literature
| S-EPMC3988194 | biostudies-literature
| S-EPMC9412239 | biostudies-literature
| S-EPMC7892317 | biostudies-literature
| S-EPMC8320593 | biostudies-literature
| S-EPMC4605593 | biostudies-literature