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ABSTRACT:
SUBMITTER: Ittisoponpisan S
PROVIDER: S-EPMC6544567 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ittisoponpisan Sirawit S Islam Suhail A SA Khanna Tarun T Alhuzimi Eman E David Alessia A Sternberg Michael J E MJE
Journal of molecular biology 20190414 11
Knowledge of protein structure can be used to predict the phenotypic consequence of a missense variant. Since structural coverage of the human proteome can be roughly tripled to over 50% of the residues if homology-predicted structures are included in addition to experimentally determined coordinates, it is important to assess the reliability of using predicted models when analyzing missense variants. Accordingly, we assess whether a missense variant is structurally damaging by using experimenta ...[more]