Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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ABSTRACT:
SUBMITTER: Farias Quipildor GE
PROVIDER: S-EPMC6544744 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
Farias Quipildor Gabriela E GE Mao Kai K Hu Zunju Z Novaj Ardijana A Cui Min-Hui MH Gulinello Maria M Branch Craig A CA Gubbi Sriram S Patel Khushbu K Moellering Douglas R DR Tarantini Stefano S Kiss Tamas T Yabluchanskiy Andriy A Ungvari Zoltan Z Sonntag William E WE Huffman Derek M DM
GeroScience 20190401 2
Disruptions in growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling have been linked to improved longevity in mice and humans. Nevertheless, while IGF-1 levels are associated with increased cancer risk, they have been paradoxically implicated with protection from other age-related conditions, particularly in the brain, suggesting that strategies aimed at selectively increasing central IGF-1 action may have favorable effects on aging. To test this hypothesis, we generated inducible, b ...[more]
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