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The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

ABSTRACT: The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently used labs being Metabolon, Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants have been followed for a median of 23 years for health outcomes including death, cancer, cardiovascular disease, diabetes, and others; many of the studies are ongoing. Available exposure-related data include common clinical measurements and behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any 2 different laboratories ranged from 6 to 121 metabolites at 5 leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range, 0.56-0.89).

SUBMITTER: Yu B

PROVIDER: S-EPMC6545286 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Yu Bing B Zanetti Krista A KA Temprosa Marinella M Albanes Demetrius D Appel Nathan N Barrera Clara Barrios CB Ben-Shlomo Yoav Y Boerwinkle Eric E Casas Juan P JP Clish Clary C Dale Caroline C Dehghan Abbas A Derkach Andriy A Eliassen A Heather AH Elliott Paul P Fahy Eoin E Gieger Christian C Gunter Marc J MJ Harada Sei S Harris Tamara T Herr Deron R DR Herrington David D Hirschhorn Joel N JN Hoover Elise E Hsing Ann W AW Johansson Mattias M Kelly Rachel S RS Khoo Chin Meng CM Kivimäki Mika M Kristal Bruce S BS Langenberg Claudia C Lasky-Su Jessica J Lawlor Deborah A DA Lotta Luca A LA Mangino Massimo M Le Marchand Loïc L Mathé Ewy E Matthews Charles E CE Menni Cristina C Mucci Lorelei A LA Murphy Rachel R Oresic Matej M Orwoll Eric E Ose Jennifer J Pereira Alexandre C AC Playdon Mary C MC Poston Lucilla L Price Jackie J Qi Qibin Q Rexrode Kathryn K Risch Adam A Sampson Joshua J Seow Wei Jie WJ Sesso Howard D HD Shah Svati H SH Shu Xiao-Ou XO Smith Gordon C S GCS Sovio Ulla U Stevens Victoria L VL Stolzenberg-Solomon Rachael R Takebayashi Toru T Tillin Therese T Travis Ruth R Tzoulaki Ioanna I Ulrich Cornelia M CM Vasan Ramachandran S RS Verma Mukesh M Wang Ying Y Wareham Nick J NJ Wong Andrew A Younes Naji N Zhao Hua H Zheng Wei W Moore Steven C SC

American journal of epidemiology 20190601 6

The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently ...[more]

PMID: 31155658

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Project description:The multidisciplinary nature and long duration of birth cohort studies allow investigation of the relationship between general and oral health and indicate the most appropriate stages in life to intervene. To date, the worldwide distribution of oral health-related birth cohort studies (OHRBCSs) has not been mapped, and a synthesis of information on methodological characteristics and outcomes is not available. We mapped published literature on OHRBCSs, describing their oral health-related data and methodological aspects. A 3-step search strategy was adopted to identify published studies using PubMed, Embase, Web of Science, and OVID databases. Studies with baseline data collection during pregnancy or within the first year of life or linked future oral health data to exposures during either of these 2 life stages were included. Studies examining only mothers' oral health and specific populations were excluded. In total, 1,721 articles were suitable for initial screening of titles and abstracts, and 528 articles were included in the review, identifying 120 unique OHRBCSs from 34 countries in all continents. The review comprised literature from the mid-1940s to the 21st century. Fifty-four percent of the OHRBCSs started from 2000 onward, and 75% of the cohorts were from high-income and only 2 from low-income countries. The participation rate between the baseline and the last oral health follow-up varied between 7% and 93%. Ten cohorts that included interventions were mostly from 2000 and with fewer than 1,000 participants. Seven data-linkage cohorts focused mostly on upstream characteristics and biological aspects. The most frequent clinical assessment was dental caries, widely presented as decayed, missing, and filled teeth (DMFT/dmft). Periodontal conditions were primarily applied as isolated outcomes or as part of a classification system. Socioeconomic classification, ethnicity, and country- or language-specific assessment tools varied across countries. Harmonizing definitions will allow combining data from different studies, adding considerable strength to data analyses; this will be facilitated by forming a global consortium.

Dataset Information

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Publications

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

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