Ontology highlight
ABSTRACT:
SUBMITTER: Roquero I
PROVIDER: S-EPMC6545338 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Roquero Irene I Cantizani Juan J Cotillo Ignacio I Manzano M Pilar MP Kessler Albane A Martín J Julio JJ McNamara Case W CW
International journal for parasitology. Drugs and drug resistance 20190522
Visceral leishmaniasis (VL) and Chagas disease (CD) are caused by kinetoplastid parasites that affect millions of people worldwide and impart a heavy burden against human health. Due to the partial efficacy and toxicity-related limitations of the existing treatments, there is an urgent need to develop novel therapies with superior efficacy and safety profiles to successfully treat these diseases. Herein we report the application of whole-cell phenotypic assays to screen a set of 150,000 compound ...[more]