Ontology highlight
ABSTRACT:
SUBMITTER: Long K
PROVIDER: S-EPMC9003639 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Long Keith K Vaughn Zoe Z McDaniels Michael David MD Joyasawal Sipak S Przepiorski Aneta A Parasky Emily E Sander Veronika V Close David D Johnston Paul A PA Davidson Alan J AJ de Caestecker Mark M Hukriede Neil A NA Huryn Donna M DM
ACS pharmacology & translational science 20220316 4
Acute kidney injury (AKI), a sudden loss of kidney function, is a common and serious condition for which there are no approved specific therapies. While there are multiple approaches to treat the underlying causes of AKI, no targets have been clinically validated. Here, we assessed a series of potent, selective competitive inhibitors of histone deacetylase 8 (HDAC8), a promising therapeutic target in an AKI setting. Using biochemical assays, zebrafish AKI phenotypic assays, and human kidney orga ...[more]