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Data on molecular characterization and expression profiles of the NF-?B repressing factor gene in red sea bream (Pagrus major).


ABSTRACT: Nuclear factor-kappaB (NF-?B) repressing factor (NKRF) specifically inhibits the transcriptional activity of NF-?B protein. The PmNKRF cDNA is composed of 757 amino acid residues. Alignment analysis revealed that the G-patch and R3H domains are conserved in different organisms. We aimed to analyse red sea bream NKRF (PmNKRF) gene expression after infection with pathogens [Streptococcus iniae or red sea bream iridovirus (RSIV)] and in healthy individuals. In healthy individuals, PmNKRF was ubiquitously expressed in all 12 tested tissues, predominantly in the head kidney and spleen. Expression of PmNKRF was significantly up-regulated in the gills, kidney, liver and spleen after RSIV infection. After S. iniae infection, PmNKRF expression was significantly down-regulated in the gills and significantly up-regulated in the kidney, liver and spleen.

SUBMITTER: Choi KM 

PROVIDER: S-EPMC6545398 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Data on molecular characterization and expression profiles of the NF-κB repressing factor gene in red sea bream (<i>Pagrus major</i>).

Choi Kwang-Min KM   Hwang Jee Youn JY   Kwon Mun-Gyeong MG   Jeong Ji-Min JM   Seo Jung Soo JS   Hwang Seong Don SD   Jee Bo-Yeong BY   Kim Mu-Chan MC   Park Chan-Il CI  

Data in brief 20190522


Nuclear factor-kappaB (NF-κB) repressing factor (NKRF) specifically inhibits the transcriptional activity of NF-κB protein. The PmNKRF cDNA is composed of 757 amino acid residues. Alignment analysis revealed that the G-patch and R3H domains are conserved in different organisms. We aimed to analyse red sea bream NKRF (PmNKRF) gene expression after infection with pathogens [<i>Streptococcus iniae</i> or red sea bream iridovirus (RSIV)] and in healthy individuals. In healthy individuals, PmNKRF was  ...[more]

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